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New drug reverses Alzheimer’s effects in mice

Yale scientists have reversed the effects of Alzheimer’s disease in mice with a new drug.

“A single dose of the drug results in improved cognitive function in mice,” lead author Paul Lombroso says in a YaleNews release. After receiving the drug, the test mice “were indistinguishable from a control group in several cognitive tasks.”

The new compound, TC-2153, results from a five-year search for drugs that block a protein called STtriatal-Enriched tyrosine Phosphatase (STEP), which interferes with learning and memory.

The team led by Lombroso, a professor in the Yale Child Study Center and in the School of Medicine’s departments of neurobiology and psychiatry, studied “thousands of small molecules” in their hunt for a STEP inhibitor, the release says. They’re now testing the compound on other animals, including rats and primates.

Their study was published August 5 in PLoS Biology.


The Yale Alumni Magazine is published by Yale Alumni Publications Inc., an alumni-based nonprofit that is not run by Yale University. Its content does not necessarily reflect the views of the university administration.

Filed under Alzheimer's, School of Medicine
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